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Latest commented articles
Identification of new high mobility group A1 associated proteins, PROTEOMICS, 2007, 10.1002/pmic.200700148
10 Comments → add new, Giovanna Maria Pierantoni, Francesco Esposito, Stéphane Giraud, Willy Vincent Bienvenut, Jean Jacques Diaz, Alfredo Fusco
High mobility group A (HMGA) proteins (HMGA1a, HMGA1b, HMGA1c and HMGA2) are nonhistone chromosomal proteins that do not have transcriptional activity per se, but they orchestrate the assembly of multiprotein complexes involved in gene transcription, replication and chromatin structure through a complex network of protein–DNA and protein–protein interactions. To better understand their mechanisms of action, we have used a combination of coimmunoprecipitation, 1‐D gel SDS‐PAGE and MS to identify new potential molecular interactors. We have found 11 proteins that associate with HMGA1. These proteins belong to three different classes: mRNA processing proteins, RNA helicases and protein chaperones. Some interactions were confirmed by coimmunoprecipitation and pull‐down experiments in human embryonal kidney 293 cells. These experimental data suggest that HMGA1 proteins can associate with proteins that are strictly involved in chromatin structure and in several important mRNA processing steps, supporting the idea that HMGA1 proteins can also participate in these events.
The pharmacology and toxicology of kratom: from traditional herb to drug of abuse, International Journal of Legal Medicine, 2015, 10.1007/s00414-015-1279-y
4 Comments → add new, Marcus L. Warner, Nellie C. Kaufman, Oliver Grundmann
Mitragyna speciosa (Rubiaceae), commonly known as kratom, is a tropical tree with a long history of traditional use in parts of Africa and Southeast Asia. In recent years, kratom has gained popularity for use as a recreational drug across the globe. Relatively new to the illicit market and used in a manner different from its traditional applications, preparations of kratom are touted by many as a safe and legal psychoactive product that improves mood, relieves pain, and may provide benefits in opiate addiction. Available literature was reviewed for M. speciosa via PubMed, Google Scholar, CINAHL, and EBSCO to summarize its traditional uses, phytochemical composition, pharmacology and toxicology of proposed active constituents, and potential for misuse and abuse. Research has demonstrated that both stimulant and sedative dose-dependent effects do exist, but a growing concern for the drug's effects and safety of use has resulted in national and international attention primarily due to an increase in hospital visits and deaths in several countries that are said to have been caused by extracts of the plant. The main active alkaloid substances in kratom, mitragynine and 7-hydroxymitragynine, present with a range of CNS stimulant and depressant effects mediated primarily through monoaminergic and opioid receptors. Recently, Palm Beach County, located in the southeastern corridor of Florida, has considered regulating kratom due to public safety concerns following the death of a young adult. At the local, state, and even federal levels, governments are now being confronted with the task of determining the safety and the possible regulation of kratom extracts. There are currently no standard analytical screening techniques for mitragynine and its metabolites following ingestion limiting its detection to more sophisticated techniques like liquid chromatography-mass spectrometry to determine kratom use. The growing concern of the abuse potential of kratom requires careful evaluation of its benefits and potential toxicities.
Spatial interpolation of daily rainfall at catchment scale: a case study of the Ourthe and Ambleve catchments, Belgium, Hydrology and Earth System Sciences Discussions, 2010, 10.5194/hessd-7-7383-2010
3 Comments → add new, S. Ly, C. Charles, A. Degré
Recombinant, Encyclopedia of Cancer, 0001, 10.1007/978-3-540-47648-1_4991
2 Comments → add new, Manfred Schwab
Unilateral gynecomastia: The assessment of 23 patients, Archives of Clinical and Experimental Surgery (ACES), 2016, 10.5455/aces.20160127010538
2 Comments → add new, Salih Basat, Fatih Ceran, Ilker Uscetin, Ismail Akan, Oguzhan Demirel, Mehmet Bozkurt
Growth Impact and Determinants of Foreing Direct Investment in Kosovo, Journal of Macroeconomic Dynamics Research, 2013, 10.12966/jmdr.11.01.2013
2 Comments → add new, Nakije Kida
Review and Comparison of Power Management Approaches for Hybrid Vehicles with Focus on Hydraulic Drives, Energies, 2014, 10.3390/en7063512
2 Comments → add new, Mohammad Karbaschian, Dirk Söffker, Mohammad Ali Karbaschian
The main advantage of hybrid powertrains is based on the efficient transfer of power and torque from power sources to the powertrain as well as recapturing of reversible energies without effecting the vehicle performance. The benefits of hybrid hydraulic powertrains can be better utilized with an appropriate power management. In this paper, different types of power management algorithms like off-line and on-line methods are briefly reviewed and classified. Finally, the algorithms are evaluated and compared. Therefore, different related criteria are evaluated and applied.
Enhanced Detection of Human Plasma Proteins on Nanostructured Silver Surfaces, Nanomaterials and Nanotechnology, 2013, 10.5772/56940
2 Comments → add new, Zuzana Orsagova, Andrej Orinak, Renata Orinakova, Lenka Skantarova, Jozef Radonak, Andrej Oriňák Zuzana Orságová Králová
Pro-generics policies and the backlog in medicines registration in South Africa: implications for access to essential and affordable medicines, Generics and Biosimilars Initiative Journal, 2015, 10.5639/gabij.2015.0402.014
2 Comments → add new, Henry MJ Leng, David Sanders, Allyson M Pollock
Proteolysis Inhibitor E-Aminocaproic Acid as Effective Drug for Prevention and Treatment of Influenza, Other Acute Respiratory Viral Infections and their Bacterial Complications, 1st International Electronic Conference on Medicinal Chemistry, 2015, 10.3390/ecmc-1-A050
9 Comments → add new, V. Lozitsky, A. Fedchuk, T. Grydina, L. Shytikova, L. Mudryk, S. Socheslo, M. Lebediuk, O. Voronkov, V. Trykhlib, A. Frolov, V. Zadorozhna, V. Buiko, S. Tkachuk